Application of polydopamine as antibacterial and anti-inflammatory materials

Abstract Polydopamine (PDA), as a material mimicking the adhesive proteins of mussels in nature, has emerged as a strong candidate for developing novel antibacterial and anti-inflammatory materials due to its outstanding biomimetic adhesion, effective photothermal conversion, excellent bio-compatibility and antioxidant capabilities. This review discussed in detail the intricate structure and polymerization principles of PDA, elucidated its mechanisms in combating bacterial infections and inflammation, as well as explored the innovative use of PDA-based composite materials for antibacterial and anti-inflammatory applications. By providing an in-depth analysis of PDA's capabilities and future research directions, this review addresses a crucial need for safer, more effective, and controllable antimicrobial and anti-inflammatory strategies, which aim to contribute to the development of advanced materials that can significantly impact public health.