长双歧杆菌
静息状态功能磁共振成像
默认模式网络
益生菌
安慰剂
医学
大脑活动与冥想
交叉研究
内科学
神经科学
心理学
功能连接
生物
双歧杆菌
病理
乳酸菌
脑电图
替代医学
细菌
遗传学
作者
Julia Rode,Hanna M. T. Edebol Carlman,Julia König,Ashley N. Hutchinson,Per Thunberg,Jonas Persson,Robert Jan Brummer
出处
期刊:Cells
[MDPI AG]
日期:2022-09-19
卷期号:11 (18): 2922-2922
被引量:8
标识
DOI:10.3390/cells11182922
摘要
Probiotics can alter brain function via the gut–brain axis. We investigated the effect of a probiotic mixture containing Bifidobacterium longum, Lactobacillus helveticus and Lactiplantibacillus plantarum. In a randomized, placebo-controlled, double-blinded crossover design, 22 healthy subjects (6 m/16 f; 24.2 ± 3.4 years) underwent four-week intervention periods with probiotics and placebo, separated by a four-week washout period. Voxel-based morphometry indicated that the probiotic intervention affected the gray matter volume of a cluster covering the left supramarginal gyrus and superior parietal lobule (p < 0.0001), two regions that were also among those with an altered resting state functional connectivity. Probiotic intervention resulted in significant (FDR < 0.05) functional connectivity changes between regions within the default mode, salience, frontoparietal as well as the language network and several regions located outside these networks. Psychological symptoms trended towards improvement after probiotic intervention, i.e., the total score of the Hospital Anxiety and Depression Scale (p = 0.056) and its depression sub-score (p = 0.093), as well as sleep patterns (p = 0.058). The probiotic intervention evoked distinct changes in brain morphology and resting state brain function alongside slight improvements of psycho(bio)logical markers of the gut–brain axis. The combination of those parameters may provide new insights into the modes of action by which gut microbiota can affect gut–brain communication and hence brain function.
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