Risk factors for elevated urinary albumin/creatinine ratio in type 2 diabetes mellitus patients over 60 years old with long-term metformin use

Patients with type 2 diabetes mellitus (T2DM) suffered renal disease with the increase of duration and age. This study aimed to analyze the risk factors for elevated urinary albumin/creatinine ratio (UACR) in T2DM patients over 60 years old with long-term metformin use. Subjects were recruited from Huanglou Community Health Centre of Shanghai from June to December 2022. A total of 466 subjects were included and divided into 2 groups according to 30 mg/g of UACR. Four hundred sixty-six T2DM patients were enrolled in this study, with UACR elevated group (n = 106) and UACR normal group (n = 360). Linear regression showed significant relation between age and UACR elevating. A correlation between urine glucose and urine protein levels was also found. The univariate logistic regression analysis showed that age, smoking, drinking, urine glucose, fatty liver, and homocysteine were related to elevated UACR (all P < .05). The multivariate logistic regression analysis showed that age, drinking, urine glucose, and fatty liver were independently related to elevated UACR elevating (all P < .05). For T2DM over 60 years old patients with long-term metformin use, aging, drinking, urine glucose, and fatty liver were independent risk factors for UACR elevating, which implied those patients should take intervention in advance.