发病机制
机制(生物学)
N6-甲基腺苷
神经病理性疼痛
生物信息学
神经科学
医学
甲基转移酶
甲基化
生物
免疫学
遗传学
基因
哲学
认识论
标识
DOI:10.1016/j.biopha.2023.115398
摘要
Neuropathic pain (NP) is a common chronic pain condition resulted from lesions or diseases of somatosensory nervous system, but the pathogenesis remains unclear. A growing body of evidence supports the relationship between pathogenesis and N6-methyladenosine (m6A) modifications of RNA. However, studies on the role of m6A modifications in NP are still at an early stage. Elucidating different etiologies is important for understanding the specific pathogenesis of NP. This article provides a comprehensive review on the role of m6A methylation modifications including methyltransferases ("writers"), demethylases ("erasers"), and m6A binding proteins ("readers") in NP models. Further analysis of the pathogenic mechanism relationship between m6A and NP provided novel theoretical and practical significance for clinical treatment of NP.
科研通智能强力驱动
Strongly Powered by AbleSci AI