PhI(OAc)2-Promoted Regioselective Cycloaddition of N-Aminopyridinium Ylides with Electron-Deficient Alkenes

Abstract Herein, we report a regioselective cycloaddition strategy of N-aminopyridinium ylides with electron-deficient alkenes, in the presence of a hypervalent iodine reagent, PhI(OAc)2. A variety of multifunctionalized pyrazolo[1,5-a]pyridine architectures were smoothly afforded by the reactions of pyridine-, quinoline-, and isoquinoline-based N-ylides with diverse alkenes with or without a halogen atom adjacent to the electron-withdrawing group (EWG) under facile conditions.