合成代谢
材料科学
骨质疏松症
辛伐他汀
钙
纳米复合材料
药理学
药物输送
药品
纳米技术
医学
内科学
冶金
作者
Zian Pan,Zhen Zhang,Xuelei Deng,Fanqi Hu,Jie Fan,Junqiang Lu,Xuesong Zhang,Xia Yang,Yujuan Gao,X Wang,Xinyue Cui,Chenlu Xu,Yan Wu
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2023-12-01
卷期号:35 (7): 075102-075102
标识
DOI:10.1088/1361-6528/ad0dc9
摘要
The limited options of anabolic drugs restricts their application potential in osteoporosis treatment, despite their theoretical superiority in therapeutic efficacy over antiresorptive drugs. As a prevailing strategy, nano-delivery systems could offer a wider choice of anabolic drugs. In this study, calcium phosphate nanocomposites incorporated with simvastatin (Sim) with periostin-targeting ability were designed and prepared for osteoporosis treatment. Carboxymethyl dextran (CMD) as an anionic and hydrophilic dextran derivative was used to stabilize CaP. In addition, periosteum-targeted peptide (SDSSD) was further grafted on CMD to achieve the bone targeting function. In a one-step coordination assembly strategy, hydrophobic anabolic agent Sim and SDSSD-CMD graft (SDSSD-CMD) were incorporated into the CaP nanoparticles forming SDSSD@CaP/Sim nanocomposites. The resulting SDSSD@CaP/Sim possesses uniform size, great short-term stability and excellent biocompatibility. Moreover, SDSSD@CaP/Sim exhibited a reduced release rate of Sim and showed slow-release behaviour. As anticipated, the nanocomposites exhibited bone bonding capacity in both cellular and animal studies. Besides, SDSSD@CaP/Sim achieved obviously enhanced osteoporosis treatment effect compared to direct injection of Sim in vivo. Therefore, our findings highlight the potential of SDSSD-incorporated and CaP-based nanocomposites as a viable strategy to enhance the therapeutic efficacy of anabolic drugs for osteoporosis treatment.
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