自愈水凝胶
伤口愈合
肉芽组织
壳聚糖
血管生成
活性氧
成纤维细胞
再生(生物学)
金黄色葡萄球菌
化学
微生物学
医学
细胞生物学
癌症研究
免疫学
细菌
高分子化学
生物化学
生物
体外
遗传学
作者
Jingchen Xu,Lin Ye,Yue Wang,Hongyu Gao,Yuanhong Li,Chaoliang Zhang,Qianming Chen,Song Chen,Qiang Peng
标识
DOI:10.1002/adhm.202303501
摘要
Abstract Repeated microbial infection, excess reactive oxygen species (ROS) accumulation, cell dysfunction, and impaired angiogenesis under hyperglycemia severely inhibit diabetic wound healing. Therefore, developing multifunctional wound dressings accommodating the complex microenvironment of diabetic wounds is of great significance. Here, a multifunctional hydrogel (Regesi‐CS) is prepared by loading regeneration silicon (Regesi) in the non‐crosslinked chitosan (CS) solution, followed by freeze‐drying and hydration. As expected, the blank non‐crosslinked CS hydrogel (1%) shows great antibacterial activity against Escherichia coli , Staphylococcus aureus , and methicillin‐resistant S. aureus (MRSA), improves fibroblast migration, and scavenges intracellular ROS. Interestingly, after loading 1% Regesi, the Regesi‐CS (1%‐1%) hydrogel shows greater antibacterial activity, significantly promotes fibroblasts proliferation and migration, scavenges much more ROS, and substantially protects fibroblasts under oxidative stress, yet Regesi alone has no or even negative effects. In the MRSA‐infected diabetic wound model, Regesi‐CS (1%‐1%) hydrogel effectively promotes wound healing by eliminating bacterial infection, enhancing granulation tissue formation, promoting collagen deposition, and improving angiogenesis. In conclusion, Regesi‐CS hydrogel may be a potential wound dressing for the effective treatment and management of chronic diabetic wounds.
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