癌症
组织微阵列
癌症研究
下调和上调
免疫组织化学
医学
生物
病理
内科学
基因
生物化学
作者
Tong Cheng,Boxuan Jiang,Manyu Xu,Chengzhe Yuan,Mingliang Tai,Hanjiang Wu,Bing Lu,Pingping Sun,Xiaohui Jiang,Xiaojing Zhang
出处
期刊:Carcinogenesis
[Oxford University Press]
日期:2022-08-31
卷期号:43 (10): 980-987
被引量:3
标识
DOI:10.1093/carcin/bgac074
摘要
Gastric cancer ranked third worldwide in terms of mortality. The immediate priority is to search for new prognosticative or therapeutic targets. This research aims to examine the function of the NADH:ubiquinone oxidoreductase subunit S4 (NDUFS4) in the malignant phenotype of gastric carcinoma. We analyzed the correlation between NDUFS4 expression and gastric cancer via bioinformatics analysis and cancer tissue microarray via immunohistochemistry. Also, we detected the phenotype change in gastric cancer cells after NDUFS4 was downregulated. NDUFS4's high expression in gastric cancer tissues showed an association with terminal TNM stage and unfavorable survival. Furthermore, downregulation of NDUFS4 decreased gastric cancer cell proliferation, migration and invasion. Nude mouse models revealed that NDUFS4 promotes tumor growth. This investigation highlights the prognostic role of NDUFS4 in gastric cancer. Our results also creatively ascertained NDUFS4 as a candidate for gastric cancer therapeutic targets.
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