Rates and Impact of Serious Adverse Events after Endovascular Thrombectomy among Large Vessel Occlusion Stroke Patients

医学 冲程(发动机) 闭塞 不利影响 心脏病学 内科学 急诊医学 机械工程 工程类
作者
Bo Lei,Shuang Yang,Ling Tian,Simin Zhou,Thanh N. Nguyen,Mohamad K Abdalkader,Xingyue Liu,Yingbin Sun,Ning Zhao,Qin Han,An Mao,Zhaojun Tao,Yan Wang,Wenfeng Cao,Shiquan Yang,Jun Zhang,Fuqiang Guo,Hongbin Wen,Jinhua Zhang,Chengsong Yue
出处
期刊:Neuroepidemiology [Karger Publishers]
卷期号:: 1-12
标识
DOI:10.1159/000540555
摘要

Objective: Complications or serious adverse events (SAEs) are common in the treatment of patients with large vessel occlusion stroke. There has been limited study of the impact of SAEs for patients after endovascular thrombectomy (EVT). The goal of this study was to characterize the rates and clinical impact of SAEs following EVT. Methods: A post hoc analysis was performed using pooled databases of the “DEVT” and “RESCUE BT” trials. SAEs were designated as symptomatic intracranial hemorrhage, brain herniation or craniectomy, respiratory failure, circulatory failure, pneumonia, deep venous thrombosis, and systemic bleeding. The primary endpoint was functional independence (modified Rankin scale score 0–2 within 90 days). Logistic regression analysis was used to determine the predictors and associations between SAEs and outcomes. Results: Of 1,182 enrolled patients, 402 (34%) had a procedural complication and 745 (63%) had 1,404 SAE occurrences with 4.65% in-hospital mortality. The three most frequent SAEs were pneumonia (620, 52.5%), systemic bleeding (174, 14.7%), and respiratory failure (173, 14.6%). Pneumonia, systemic bleeding, or deep venous thrombosis was less life-threatening. Patients with advanced age (adjusted odds ratio, 1.28 [95% confidence interval, 1.14–1.43]), higher NIHSS (1.09 [1.06–1.11]), occlusion site (middle cerebral artery-M1 vs. internal carotid artery [ICA]: 0.75 [0.53–1.04]; M2 vs. ICA: 1.30 [0.80–2.12]), longer procedure time (1.01 [1.00–1.01]), and unsuccessful vessel recanalization (1.79 [1.06–2.94]) were more likely to experience SAEs. Compared with no SAE, patients with SAEs had lower odds of functional independence (0.46 [0.40–0.54]). Conclusions: Overall, SAEs diagnosed following thrombectomy in patients with stroke were common (more than 60%) and associated with functional dependence. Patients with advanced age, higher NIHSS, longer procedure time, and failed recanalization were more likely to experience SAEs. There was no statistical difference in the risk of SAEs among patients with M1 and M2 occluded compared with those ICA occluded. An understanding of the prevalence and predictors of SAEs could alert clinicians to the estimated risk of an SAE for a patient after EVT.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
无花果应助178181采纳,获得10
刚刚
1秒前
科研通AI2S应助林八八采纳,获得10
1秒前
1秒前
DM完成签到,获得积分10
1秒前
纯真冰蝶发布了新的文献求助10
2秒前
叁金完成签到,获得积分10
3秒前
wanci应助Ricewind采纳,获得10
3秒前
默默完成签到,获得积分20
3秒前
烟花应助楚岸采纳,获得10
3秒前
3秒前
3秒前
CodeCraft应助小巧凝竹采纳,获得10
4秒前
4秒前
bio-tang发布了新的文献求助10
4秒前
英姑应助鹤川采纳,获得10
5秒前
spcwlh完成签到,获得积分10
5秒前
汉堡包应助mizhou采纳,获得10
6秒前
QJ发布了新的文献求助10
6秒前
6秒前
Daily完成签到,获得积分10
6秒前
6秒前
默默发布了新的文献求助30
7秒前
7秒前
yar应助余姚采纳,获得10
7秒前
秋子完成签到,获得积分10
7秒前
思维隋发布了新的文献求助10
8秒前
hileborn完成签到,获得积分10
9秒前
子车老头完成签到,获得积分10
9秒前
9秒前
Lucas应助shen采纳,获得10
9秒前
Aray完成签到,获得积分10
10秒前
10秒前
赘婿应助动静结合采纳,获得10
10秒前
nancy发布了新的文献求助10
11秒前
兰天发布了新的文献求助30
11秒前
善学以致用应助情殇采纳,获得10
11秒前
bingbing完成签到,获得积分10
11秒前
量子星尘发布了新的文献求助10
11秒前
浅言完成签到 ,获得积分10
11秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 1000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3979122
求助须知:如何正确求助?哪些是违规求助? 3522967
关于积分的说明 11215682
捐赠科研通 3260436
什么是DOI,文献DOI怎么找? 1799990
邀请新用户注册赠送积分活动 878770
科研通“疑难数据库(出版商)”最低求助积分说明 807061