转录因子
计算生物学
基因
生物
遗传学
抄写(语言学)
转录组
背景(考古学)
生物信息学
基因表达
语言学
哲学
古生物学
作者
Fanchen Wang,Xiaolin Xu,Xin Li,Jia Yuan,Xuzhu Gao,Chenglong Wang,Wencai Guan,Guoxiong Xu
标识
DOI:10.1002/1878-0261.13388
摘要
Transcription factors (TFs) are key players in the regulation of gene transcription in mammalian cells. Although high‐throughput screening can be used to identify differentially expressed genes between comparable groups, the precision of the corresponding datasets is far from optimal. Here, we establish Target Finder of Transcription Factor (TFoTF), a method for the prediction of TF‐targeted genes from genomic and cancer‐related transcriptomic data. TFoTF can identify potential TF‐targeted genes in large cancer datasets and efficiently estimate correlations between TFs and their targeted genes with a significant level of specificity, sensitivity, and precision. Overall, TFoTF is an easy‐to‐use tool that can be utilized to generate testable hypotheses in the context of cancer research projects.
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