化学
立体化学
生物活性
天然产物
手性(物理)
生物化学
夸克
Nambu–Jona Lasinio模型
手征对称破缺
量子力学
物理
体外
作者
Xin Fang,Ying Di,Yu Zhang,Zhi Ping Xu,Yang Lű,Qian Qian Chen,Qi-Teng Zheng,Xiao Jiang Hao
标识
DOI:10.1002/anie.201412126
摘要
Abstract Perforalactone A ( 1 ), a new 20 S quassinoid with a unique cagelike 2,4‐dioxaadamantane ring system and a migrated side chain, was isolated from the plant Harrisonia perforata together with two biosynthetically related new quassinoids. The structures of these natural products were elucidated by NMR spectroscopy, X‐ray diffraction analysis, computational modeling, and the CD excitation chirality method. The compounds exhibited notable biological properties, including insecticidal activity against Aphis medicaginis Koch and antagonist activity at the nicotinic acetylcholine receptor of Drosophila melanogaster . The structural features of these compounds may be related to their promising biological characteristics. Their biosynthesis and an alternative origin of quassinoid‐type natural products are also discussed.
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