Catalytic Asymmetric Synthesis of Optically Active Atropisomeric Anilides through Enantioselective N-Allylation with Chiral Pd-tol-BINAP Catalyst

Catalytic asymmetric N-allylation reaction of ortho-tert-butylanilide derivatives with diallyl carbonate proceeds in the presence of tol-BINAP-Pd catalyst to give chiral N-allyl ortho-tert-butylanilides of 32-44%ee in excellent chemical yields (> or = 90%).