前药
异丙酚
溶解度
医学
体内
药理学
色谱法
化学
有机化学
生物
生物技术
作者
Bingchen Lang,Jun Yang,Yu Wang,Yun Luo,Yi Kang,Jin Liu,Wensheng Zhang
标识
DOI:10.1213/ane.0000000000000124
摘要
Application of the amino acid group to the propofol prodrug can make the prodrug have good water solubility and a more rapid onset of action. In rat plasma, the 2 improved amino acid prodrugs (HX0969-Ala-HCl, HX0969-Gly-F3) had a more rapid rate of propofol release than the 2 phosphate ester prodrugs (fospropofol, HX0969W). The in vivo tests showed that HX0969-Ala-HCl and HX0969-Gly-F3 given IV could have a more rapid onset of action in a smaller dose than fospropofol and HX0969W. This novel design can enhance the efficiency of prodrugs converting to propofol.
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