布鲁顿酪氨酸激酶
自身免疫
B细胞受体
B细胞
断点群集区域
免疫学
生物
酪氨酸激酶
癌症研究
信号转导
细胞生物学
免疫系统
受体
抗体
遗传学
作者
Odilia B. J. Corneth,Roel G. J. Klein Wolterink,Rudi W. Hendriks
出处
期刊:Current Topics in Microbiology and Immunology
日期:2015-01-01
卷期号:: 67-105
被引量:76
摘要
Since the original identification of Bruton's tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in vivo, both in the regulation of expansion and in the developmental progression of pre-B cells in the bone marrow and as a crucial signal transducer of signals downstream of the IgM or IgG B cell antigen receptor (BCR) in mature B cells governing proliferation, survival, and differentiation. In particular, we highlight BTK function in B cells in the context of host defense and autoimmunity. Small-molecule inhibitors of BTK have very recently shown impressive anti-tumor activity in clinical studies in patients with various B cell malignancies. Since promising effects of BTK inhibition were also seen in experimental animal models for lupus and rheumatoid arthritis, BTK may be a good target for controlling autoreactive B cells in patients with systemic autoimmune disease.
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