肌萎缩
肌萎缩性肥胖
背景(考古学)
肥胖
骨量减少
骨质疏松症
瘦素
医学
内分泌学
内科学
生物信息学
生物
骨矿物
古生物学
作者
Jasminka Z. Ilich,Owen Kelly,Julia E Inglis,Lynn B. Panton,Gustavo Duque,Michael J. Ormsbee
标识
DOI:10.1016/j.arr.2014.02.007
摘要
While sarcopenia and sarcopenic obesity have been recognized in the last decade, a combined concept to include decreased muscle mass and strength, as well as decreased bone mass with coexistence of adiposity is discussed here. We introduce a new term, osteopenic obesity, and operationalize its meaning within the context of osteopenia and obesity. Next, we consolidate osteopenic obesity with the already existing and more familiar term, sarcopenic obesity, and delineate the resulting combined condition assigning it the term osteosarcopenic obesity. Identification and possible diagnosis of each condition are discussed, as well as the interactions of muscle, fat and bone tissues on cellular level, considering their endocrine features. Special emphasis is placed on the mesenchymal stem cell commitment into osteoblastogenic, adipogenic and myogenic lineages and causes of its deregulation. Based on the presented evidence and as expounded within the text, it is reasonable to say that under certain conditions, osteoporosis and sarcopenia could be the obesity of bone and muscle, respectively, with the term osteosarcopenic obesity as an encompassment for all.
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