Exploring natural products for insomnia: Effective solutions for better sleep

Abstract Insomnia, affecting millions worldwide, is a prevalent sleep disorder characterized by persistent difficulties in both initiating and maintaining sleep, leading to compromised daytime functioning, heightened risks of cardiovascular and psychiatric comorbidities, and substantial socioeconomic burdens necessitating the pursuit of safer and more efficacious therapeutic interventions. This review systematically evaluated research studies published between 2020 and 2024 on 71 natural product‐based insomnia treatments—classified by chemical structure (terpenoids, flavonoids, and polyphenols)—and investigated their underlying GABAergic, serotonergic, and antioxidative mechanisms using both in vivo and in vitro evidence to elucidate potential multi‐target benefits. In sum, although natural products represent a promising avenue for safer multi‐faceted insomnia management, additional rigorous clinical studies and integrative methodologies are critical to establish efficacy, delineate molecular mechanisms, and advance these agents toward more precise and sustainable therapeutic applications.