四嗪
体内
环加成
组合化学
化学
生物正交化学
环辛烯
食腐动物
催化作用
点击化学
生物化学
有机化学
激进的
生物
生物技术
作者
Thomas Reiner,Edmund J. Keliher,Sarah Earley,Brett Marinelli,Ralph Weissleder
标识
DOI:10.1002/anie.201006579
摘要
Pedal to the metal: The catalyst-free Diels–Alder cycloaddition of trans-cyclooctene and tetrazine was used to quickly and selectively generate an 18F-labeled AZD2281 derivative from a tetrazine-linked precursor. The probe was tested in biological assays, and its targeted accumulation was confirmed in vivo. This protocol allows the parallel synthesis of a library of potential PET imaging agents in a short time, thus increasing the efficiency of lead compound development.
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