催化作用
化学
纳米技术
配体(生物化学)
组合化学
比例(比率)
有机化学
材料科学
受体
物理
生物化学
量子力学
作者
A. Buitrago Santanilla,Erik L. Regalado,Tony Pereira,Michael Shevlin,Kevin P. Bateman,Louis‐Charles Campeau,Jonathan E. Schneeweis,Simon Berritt,Zhicai Shi,Philippe G. Nantermet,Yong Liu,Roy Helmy,Christopher J. Welch,Petr Váchal,Ian W. Davies,Tim Cernak,Spencer D. Dreher
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2014-11-21
卷期号:347 (6217): 49-53
被引量:631
标识
DOI:10.1126/science.1259203
摘要
Breaking through the milligram floor When chemists synthesize compounds, the threshold for success is at least a milligram of product. This has been true for decades—even though biochemical assays have long since descended into microgram territory—and results in part from the constraints of characterization methods. Buitrago Santanilla et al. present an automated dosing and characterization protocol for optimizing chemical reaction conditions on the microgram scale. This allowed them to screen numerous base and ligand combinations for catalytic C-N bond-forming reactions between complex pairs of compounds, in short supply, that resisted standard coupling conditions. Science , this issue p. 49
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