丁香假单胞菌
生物
效应器
拟南芥
先天免疫系统
植物免疫
毒力
激酶
细胞生物学
病菌
受体
微生物学
基因
遗传学
突变体
作者
T. Xiang,Na Zong,Yan Zou,Yong Wu,Jie Zhang,Weiman Xing,Yan Li,Xiaoyan Tang,Li Zhu,Jijie Chai,Jian‐Min Zhou
出处
期刊:Current Biology
[Elsevier BV]
日期:2008-01-01
卷期号:18 (1): 74-80
被引量:465
标识
DOI:10.1016/j.cub.2007.12.020
摘要
Plants use receptor kinases, such as FLS2 and EFR, to perceive bacterial pathogens and initiate innate immunity. This immunity is often suppressed by bacterial effectors, allowing pathogen propagation. To counteract, plants have evolved disease resistance genes that detect the bacterial effectors and reinstate resistance. The Pseudomonas syringae effector AvrPto promotes infection in susceptible plants but triggers resistance in plants carrying the protein kinase Pto and the associated resistance protein Prf. Here we show that AvrPto binds receptor kinases, including Arabidopsis FLS2 and EFR and tomato LeFLS2, to block plant immune responses in the plant cell. The ability to target receptor kinases is required for the virulence function of AvrPto in plants. The FLS2-AvrPto interaction and Pto-AvrPto interaction appear to share similar sequence requirements, and Pto competes with FLS2 for AvrPto binding. The results suggest that the mechanism by which AvrPto recognizes virulence targets is linked to the evolution of Pto, which, in association with Prf, recognizes the bacterium and triggers strong resistance.
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