Antioxidative Glutathione Peroxidase Activity of Selenoglutathione

Pep talk: Selenoglutathione (GSeH) and other peptides containing selenocysteine with an amino acid sequence of the glutathione peroxidase (GPx) active site are obtained in the oxidized form by solid-phase peptide synthesis. Their GPx activity against hydrogen peroxide (see picture) reveals that GSeH has effective antioxidant activity in addition to the biological function of a glutathione analogue.