生物
基因
转录因子
原癌基因蛋白质c-myc
计算生物学
遗传学
基因表达谱
基因表达
抄写(语言学)
语言学
哲学
作者
Martin Eilers,Robert N. Eisenman
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:2008-10-15
卷期号:22 (20): 2755-2766
被引量:861
摘要
The role of the myc gene family in the biology of normal and cancer cells has been intensively studied since the early 1980s. myc genes, responding to diverse external and internal signals, express transcription factors (c-, N-, and L-Myc) that heterodimerize with Max, bind DNA, and modulate expression of a specific set of target genes. Over the last few years, expression profiling, genomic binding studies, and genetic analyses in mammals and Drosophila have led to an expanded view of Myc function. This review is focused on two major aspects of Myc: the nature of the genes and pathways that are targeted by Myc, and the role of Myc in stem cell and cancer biology.
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