辅活化剂
心力衰竭
心功能曲线
生物
细胞生物学
疾病
转录因子
功能(生物学)
心脏发育
内分泌学
内科学
神经科学
生物信息学
遗传学
医学
基因
胚胎干细胞
作者
Glenn C. Rowe,Aihua Jiang,Zolt Arany
出处
期刊:Circulation Research
[Ovid Technologies (Wolters Kluwer)]
日期:2010-10-01
卷期号:107 (7): 825-838
被引量:299
标识
DOI:10.1161/circresaha.110.223818
摘要
The beating heart requires a constant flux of ATP to maintain contractile function, and there is increasing evidence that energetic defects contribute to the development of heart failure. The last 10 years have seen a resurgent interest in cardiac intermediary metabolism and a dramatic increase in our understanding of transcriptional networks that regulate cardiac energetics. The PPAR-γ coactivator (PGC)-1 family of proteins plays a central role in these pathways. The mechanisms by which PGC-1 proteins regulate transcriptional networks and are regulated by physiological cues, as well as the roles they play in cardiac development and disease, are reviewed here.
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