表观遗传学
腺苷
腺苷受体
功能(生物学)
受体
基因剔除小鼠
生物
基因
基因敲除
计算生物学
G蛋白偶联受体
细胞外
细胞生物学
遗传学
神经科学
生物化学
兴奋剂
标识
DOI:10.1016/s0165-6147(99)01305-x
摘要
The extensive role of adenosine in discriminating input from the extracellular environment is effected through a series of cell membrane-spanning proteins--the adenosine A1, A2A, A2B and A3 receptors. New genetic and epigenetic tools have emerged that facilitate the elucidation of the function of these receptors with greater specificity than is generally possible with traditional antagonist drugs. These tools include antisense oligonucleotides (epigenetic) and gene 'knockin' and 'knockout' mice (genetic) and are discussed in this article by Jonathan Nyce.
科研通智能强力驱动
Strongly Powered by AbleSci AI