胶束
纳米载体
化学
两亲性
聚乙二醇化
乙二醇
阳离子聚合
共聚物
高分子化学
酰胺
药物输送
PEG比率
有机化学
聚合物
水溶液
聚乙二醇
财务
经济
作者
Gongyan Liu,Min Li,Congshan Zhu,Qiao Jin,Zongcai Zhang,Jian Ji
标识
DOI:10.1002/mabi.201400162
摘要
A novel amphiphilic copolymer, poly (ethylene glycol)-graft-polyethyleneimine/amide (PEG-g-PEI/amide), is synthesized by grafting PEG and1,2-cis-Cyclohexanedicarboxylic anhydride onto the PEI. PEGylated polymeric micelles can be assembled from the amphiphilic copolymers with well-defined nano-sizes, and anti-cancer drugs are successfully loaded into micelle core formed by the amide. The amides with neighboring carboxylic acid groups exhibit pH-dependent hydrolysis and can reversibly shield the cationic charge of amine groups on the PEI, giving the micelles a charge-conversion property from negative to positive in acidic tumor tissue environment. Meanwhile, the cleavage of amide bonds at acidic pH also results in the disassembly of the micelle and pH-responsive drug release. These micelles are promising drug delivery systems due to their smart properties: PEGylation, suitable size, charge-conversion, and simultaneous pH-sensitive drug release.
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