细胞因子诱导的杀伤细胞
生物
CD3型
自然杀伤性T细胞
主要组织相容性复合体
淋巴因子激活杀伤细胞
免疫学
自然杀伤细胞
细胞
白细胞介素21
癌症研究
T细胞
细胞毒性T细胞
免疫系统
CD8型
生物化学
体外
作者
Xiaomeng Wang,Wenwen Yu,Hui Li,Jinpu Yu,Xinwei Zhang,Xiubao Ren,Shui Cao
标识
DOI:10.1016/j.cellimm.2013.11.009
摘要
Cytokine-induced killer (CIK) cells, which display both potent anti-tumor ability of T lymphocytes and non-major histocompatibility complex (MHC) restricted killing tumor cells capacity of natural killer (NK) cells are capable of recognizing and lysing a broad array of tumor targets. They have begun to be used in clinical care with good prospects for treatment success. CIK cells are a heterogeneous cell population that contain CD3+CD56+ cells, CD3−CD56+ natural killer (NK) cells and CD3+CD56− T cells on which much attention has been focused. This review will summarize the connections and differences among CD3+CD56+CIK cells, CD3−CD56+ NK cells and CD3+CD56− T cells in the following aspects: the main cell surface molecule, killing mechanism, and clinical applications so that treatment with CIK cells can be optimized and further to enhance the antitumor effect.
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