毒蕈碱乙酰胆碱受体
化学
乙酰胆碱
奥尼姆
增强剂
受体
兴奋剂
立体化学
生物物理学
药理学
生物化学
生物
离子
有机化学
作者
Lemont B. Kier,Lowell H. Hall
标识
DOI:10.1002/jps.2600671021
摘要
A correlation between three molecular connectivity indexes and the muscarinic receptor affinity of 104 acetylcholine antagonists was found. Analysis of structure from these indexes reveals not only the importance of the onium and the bulky portions of the molecule but also their virtual independence of each other on the affinity. Analysis of the onium group portion of the molecules indicates that its contribution to the experimental affinity is virtually constant through a variety of structural variations. The influence of the bulky side chains, in contrast, is quite structure dependent. The equation relating connectivity indexes to muscarinic affinity of antagonists is capable of predicting the affinity of other antagonists as well as a number of agonist molecules.
科研通智能强力驱动
Strongly Powered by AbleSci AI