溃疡性结肠炎
失调
新陈代谢
益生菌
肠道菌群
化学
微生物群
结肠炎
胃肠病学
微生物学
生物化学
内科学
医学
生物
生物信息学
细菌
疾病
遗传学
作者
Jun Fan,Weilin Jin,Su Shaochen,Aman Khan,Ying Wu,Yanyi Chen,Ping Feng,Jeon Byong‐Hun,Shereen Elsayed,Ling Zhenmin,Pu Liu,Li Xiangkai
标识
DOI:10.1002/mnfr.202300731
摘要
Gut microbiota (GM) dysbiosis and dysregulated bile acids (BAs) metabolism have been linked to ulcerative colitis (UC) pathogenesis. The possibility of utilizing live probiotics with a defined BAs-metabolizing capability to modify the composition BAs for UC treatment remains unexplored.In this study, Strain GR-4 is sourced from traditional Chinese fermented food, "Jiangshui," and demonstrated the ability to deconjugate two common conjugated BAs by over 69% and 98.47%, respectively. It administers strain GR-4 to dextran sulfate sodium (DSS)-induced UC mice, and observes an overall alleviation of UC symptoms, as evidence by improved colon morphology, reduces inflammation and oxidative stress, and restores intestinal barrier function. Importantly, these effects are reliant on an intact commensal microbiota, as depletion of GM mitigated GR-4s efficacy. Metabolomics analysis unveils a decline in conjugated BAs and an increase in secondary BAs following GR-4 administration. GM analysis indicates that GR-4 selectively enriches bacterial taxa linked to BAs metabolism, enhancing GM's capacity to modify BAs.This research demonstrates the potential for natural fermented foods and probiotics to effectively manipulate BAs composition, including conjugated and secondary BAs, to alleviate UC symptoms, underscoring the benefits of these approaches for gut health.
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