自愈水凝胶
生物利用度
化学
二醇
自愈
化学工程
核化学
有机化学
药理学
医学
替代医学
病理
工程类
作者
Long Yuan,Xinyun Liu,Jie Xiong,Hua Lee
标识
DOI:10.1080/01932691.2024.2340674
摘要
In this report, new self-healing hydrogels were obtained through simple one-pot free radical polymerization of acrylamide, phenylboronic acid, and 2-hydroxyethyl acrylate as copolymer monomers, potassium persulfate (KPS) as initiator, and tetramethylethylenediamine (TEMED) as promoter under low-temperature alkaline (pH = 9) conditions. The boronic acid group of phenylboronic acid (PBA) can interact with the hydroxyl group of hydroxyethyl acrylate (HEA) to form dynamic boronic ester bonds instead of the conventional bis acrylate crosslinkers. The effect of PBA content on the mechanical strength of the hydrogels was systematically investigated. The hydrogels exhibited higher stress, elongation, and self-healing properties due to the synergistic effect of H-bonds and boronate-diol complexation. Further studies revealed that the A–H–0.2–P–0.08 hydrogels exhibited excellent resistance to compression fatigue and also showed good biocompatibility through in vitro cytotoxicity tests.
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