粒体自噬
转位酶
线粒体
细胞生物学
生物
线粒体内膜
生物化学
自噬
基因
染色体易位
细胞凋亡
作者
Mohamed A. Eldeeb,Andrea Soumbasis,Edward A. Fon
标识
DOI:10.1016/j.tem.2023.05.005
摘要
Given their polyvalent roles, an intrinsic challenge that mitochondria face is the continuous exposure to various stressors including mitochondrial import defects, which leads to their dysfunction. Recent work has unveiled a presequence translocase-associated import motor (PAM) complex-dependent quality control pathway whereby misfolded proteins mitigate mitochondrial protein import and subsequently elicit mitophagy without the loss of mitochondrial membrane potential.
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