HBx公司
肝癌
癌症研究
基因
生物
疾病
免疫系统
癌症
免疫学
计算生物学
乙型肝炎病毒
生物信息学
医学
遗传学
肝细胞癌
病毒
病理
作者
Ai L,Qingqing Liu,Yize Li,Yuanyuan Wang,Hongmei Zhang
摘要
HBX gene is essential for HBV replication, evading the surveillance of the immune system by integrating its sequence into the human genome. It also exists stably in human cells by inhibiting the expression and activity of mismatch repair-related pathway genes. Previous reviews have comprehensively summarized the role of HBx in liver-related diseases. Our article complements the summary of research on HBx in diseases other than liver disease. Through a comprehensive literature search and reading, we found that HBx is expressed in the kidney, placenta, lung and other organs of HBV-infected patients, and is closely related to the occurrence and development of diseases such as nephritis, diffuse large B-cell lymphoma, and gastric cancer. However, in the clinical treatment of these diseases, HBV infection and the role of HBx have not attracted sufficient attention, and there is no corresponding treatment strategy. Therefore, more research on HBx in diseases other than the liver is particularly necessary, and we hope that our article can provide some insight into the treatment of related diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI