神经科学
诱导多能干细胞
冲程(发动机)
移植
加巴能
皮质(解剖学)
运动皮层
人脑
干细胞
类有机物
生物
医学
胚胎干细胞
内科学
细胞生物学
基因
抑制性突触后电位
机械工程
生物化学
刺激
工程类
作者
Shi-Ying Cao,Mengdan Tao,Shu Lou,Di Yang,Yu Hui Lin,Hai‐Yin Wu,Lei Chang,Chunxia Luo,Yun Xu,Yan Liu,Dong‐Ya Zhu
标识
DOI:10.1016/j.bbrc.2023.06.010
摘要
Stroke is the leading cause of death and long-term disability worldwide. But treatments are not available to promote functional recovery, and efficient therapies need to be investigated. Stem cell-based therapies hold great promise as potential technologies to restore function in brain disorders. Loss of GABAergic interneurons after stroke may result in sensorimotor defects. Here, by transplanting human brain organoids resembling the MGE domain (human MGE organoids, hMGEOs) derived from human induced pluripotent stem cells (hiPSCs) into the infarcted cortex of stroke mice, we found that grafted hMGEOs survived well and primarily differentiated into GABAergic interneurons and significantly restored the sensorimotor deficits of stroke mice for a long time. Our study offers the feasibility of stem cell replacement therapeutics strategy for stroke.
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