番红花
医学
止痛药
慢性疼痛
伤害
纤维肌痛
药理学
类风湿性关节炎
麻醉
传统医学
物理疗法
内科学
受体
作者
Ali Mohammad Pourbagher‐Shahri,Fatemeh Forouzanfar
摘要
Abstract Pain can become a chronic and deliberating experience with a significant burden. In preclinical and clinical studies, Saffron ( Crocus sativus L.) has shown analgesic activities. Considering the unsatisfactory results of current therapeutic management for chronic pain conditions, we aimed to review saffron's analgesic activity and underlying mechanisms. Saffron showed antinociceptive activities in formalin‐, carrageenan‐, and capsaicin‐induced experimental pain models. Saffron analgesic activities affected several targets, including ion channels of nociceptors; the adrenergic system and central histaminic system; inhibition of inflammatory pathways, apoptotic pathways, and oxidative stress; regulation of NO pathway, and the endocannabinoid system. Clinical studies showed analgesia of Saffron in rheumatoid arthritis, after‐pain following childbirth, dysmenorrhea, and fibromyalgia. Our literature review showed that saffron can be beneficial as an adjunct therapy to commonly used analgesics in practice, particularly in chronic pain conditions.
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