医学
中止
急性全身发疹性脓疱病
罪魁祸首
药物不良反应
嗜酸性粒细胞增多症
皮肤病科
Exanthem公司
药品
过敏反应
鉴别诊断
戒毒
中毒性表皮坏死松解
重症监护医学
免疫学
病理
内科学
药理学
心肌梗塞
作者
Annika Weinhammer,Lindy P. Fox,Benjamin H. Kaffenberger,Abraham M. Korman,Robert G. Micheletti,Arash Mostaghimi,Megan H. Noe,Misha Rosenbach,Kanade Shinkai,Jason Kwah,Elizabeth Phillips,Jean L. Bolognia,William Damsky,Caroline A. Nelson
标识
DOI:10.1016/j.jaad.2023.02.073
摘要
Drug-induced hypersensitivity syndrome, also known as drug reaction with eosinophilia and systemic symptoms, is a severe cutaneous adverse reaction characterized by an exanthem, fever, and hematologic and visceral organ involvement. The differential diagnosis includes other cutaneous adverse reactions, infections, inflammatory and autoimmune diseases, and neoplastic disorders. Three sets of diagnostic criteria have been proposed; however, consensus is lacking. The cornerstone of management is immediate discontinuation of the suspected drug culprit. Systemic corticosteroids remain first-line therapy, but the literature on steroid-sparing agents is expanding. Longitudinal evaluation for sequelae is recommended. Adjunctive tests for risk stratification and drug culprit identification remain under investigation. Part II of this continuing medical education activity begins by exploring the differential diagnosis and diagnosis of drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms and concludes with an evidence-based overview of evaluation and treatment.
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