内分泌干扰物
尿
对羟基苯甲酸酯
二羟基化合物
医学
双酚A
尼泊金甲酯
环境卫生
卫生专业人员
内分泌系统
医疗保健
检查表
化妆品
心理学
化学
内科学
激素
防腐剂
环氧树脂
经济
认知心理学
经济增长
病理
食品科学
有机化学
作者
Julien Robin,Marion Albouy,Bernard Jourdain,Guillaume Binson,Alexis Sauvaget,Pascale Pierre-Eugène,Luyao Wu,Virginie Migeot,Antoine Dupuis,Nicolas Venisse
出处
期刊:Therapeutic Drug Monitoring
[Ovid Technologies (Wolters Kluwer)]
日期:2023-08-08
标识
DOI:10.1097/ftd.0000000000001132
摘要
Background: In 2021, French public authorities initiated the fourth National Environmental Health Plan to prevent environment-related health risks. This plan primarily focuses on the sensitization of health professionals and health care institutions. Endocrine disruptors (EDs) are environmental factors associated with several adverse health effects, such as reproductive disorders, obesity, and cancer. This study aimed to conduct an awareness campaign among professionals at a general hospital center on the risks related to EDs. Methods: Hospital professionals were directly involved in this study, and urine and hair samples were collected to determine bisphenol and paraben exposure levels. Analyses were performed using validated liquid chromatography-tandem mass spectrometry methods, enabling the simultaneous determination of bisphenols and parabens. A questionnaire on lifestyle habits was distributed to assess its relationship with the exposure profiles. Nineteen professionals were recruited for the study. Results: Bisphenol A was detected in 95% of the urine samples, and the chlorinated derivatives of bisphenol A were between 16% and 63%. parabens showed detection frequencies between 37% and 100%, and methylparaben was quantified at an average concentration of 0.45 ± 0.46 ng/mL. In hair samples, bisphenols A, F, and S were detected at 95%–100%, chlorinated derivatives of bisphenol A were detected at 37%–68%, and parabens were detected at 100%. Conclusions: This awareness campaign may encourage health care institutions to adopt a policy of reducing endocrine disruptor exposure among their patients and professionals, who could be educated regarding the risks associated with EDs. Conducting a multicenter study to refine the results herein and establish a dynamic to prevent endocrine disruptor and environmental risks in health care systems would be valuable.
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