Redefining Early Diagnosis: Quantitative Susceptibility Mapping at MRI Forecasts Onset of Mild Cognitive Impairment

HomeRadiologyVol. 316, No. 3 PreviousNext Reviews and CommentaryEditorialRedefining Early Diagnosis: Quantitative Susceptibility Mapping at MRI Forecasts Onset of Mild Cognitive ImpairmentV. Carlota Andreu-Arasa1 V. Carlota Andreu-Arasa1 Author Affiliations1Boston University, VA Boston Health Care System, Boston Medical Center, One Boston Medical Center Place, Boston, MA 02118Address correspondence to: the author (email: [email protected]).V. Carlota Andreu-Arasa1 Published Online:Sep 9 2025https://doi.org/10.1148/radiol.252398See also the article by Chen et al in this issue.MoreSectionsFull textPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In References1. Jongsiriyanyong S, Limpawattana P. Mild Cognitive Impairment in Clinical Practice: A Review Article. Am J Alzheimers Dis Other Demen 2018;33(8):500–507. Medline Google Scholar2. 2024 Alzheimer's disease facts and figures. Alzheimers Dement 2024;20(5):3708–3821. Medline Google Scholar3. Gustavsson A, Norton N, Fast T, et al. Global estimates on the number of persons across the Alzheimer's disease continuum. Alzheimers Dement 2023;19(2):658–670. Medline Google Scholar4. Wong W. Economic burden of Alzheimer disease and managed care considerations. Am J Manag Care 2020;26(8 Suppl):S177–S183. Medline Google Scholar5. Dubois B, Villain N, Schneider L, et al. Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation. JAMA Neurol 2024;81(12):1304–1311. Medline Google Scholar6. Dubois B, Hampel H, Feldman HH, et al. Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement 2016;12(3):292–323. Medline Google Scholar7. Mosconi L, Pupi A, De Leon MJ. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann N Y Acad Sci 2008;1147:180–195. Medline Google Scholar8. Xu J, Shen R, Qian M, et al. Ferroptosis in Alzheimer's Disease: The Regulatory Role of Glial Cells. J Integr Neurosci 2025;24(4):25845. Medline Google Scholar9. Cogswell PM, Wiste HJ, Senjem ML, et al. Associations of quantitative susceptibility mapping with Alzheimer's disease clinical and imaging markers. Neuroimage 2021;224:117433. Medline Google Scholar10. Chen L, Soldan A, Faria A, et al; BIOCARD Study Team. Susceptibility MRI helps predict mild cognitive impairment onset and cognitive decline in cognitively unimpaired older adults. Radiology 2025;316(3):e250513. Google ScholarArticle HistoryReceived: Aug 3 2025Revision requested: Aug 6 2025Revision received: Aug 7 2025Accepted: Aug 12 2025Published online: Sept 09 2025 FiguresReferencesRelatedDetailsAccompanying This ArticleSusceptibility MRI Helps Predict Mild Cognitive Impairment Onset and Cognitive Decline in Cognitively Unimpaired Older AdultsSep 9 2025Radiology Vol. 316, No. 3 Metrics Altmetric Score PDF download