糖尿病前期
海马体
医学
认知功能衰退
认知
神经科学
内分泌学
心理学
内科学
糖尿病
痴呆
2型糖尿病
疾病
作者
Menglu Zhou,Xiaoying Yang,Xing Ge,Jiajia Chen,Wenbin Wu,Mingxuan Zheng,Xiaocheng Zhu,Xiaoying Cui,Renxian Tang,Kuiyang Zheng,Xu‐Feng Huang,Libin Yao,Yinghua Yu
出处
期刊：Diabetes
[American Diabetes Association]
日期：2025-07-10
卷期号：74 (9): 1499-1511
摘要
The present study reveals a previously unknown molecular mechanism linking prediabetes to neurodegeneration, addressing a critical gap in understanding metabolic-neurological interplay. We investigated whether PTP1B mediates prediabetes-induced cognitive impairment. PTP1B impaired synaptic signaling and synaptic ultrastructure in hippocampal neurons, contributing to cognitive decline in prediabetes. PTP1B is a novel therapeutic target for prediabetes-associated neurodegeneration.
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(2025-6-4)
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