间充质干细胞
再生医学
再生(生物学)
药物发现
计算生物学
生物
生物信息学
干细胞
医学
细胞生物学
作者
Qi Gao,Mehmet Sertac Cekuc,Yasemin Sude Ergul,Alexa K. Pius,Issei Shinohara,Masatoshi Murayama,Yosuke Susuki,Chao Ma,Mayu Morita,Simon Kwoon‐Ho Chow,Stuart B. Goodman
出处
期刊:Bioengineering
[Multidisciplinary Digital Publishing Institute]
日期:2024-11-27
卷期号:11 (12): 1199-1199
标识
DOI:10.3390/bioengineering11121199
摘要
Mesenchymal stem cells (MSCs) play an important role in regenerative medicine and drug discovery due to their multipotential differentiation capabilities and immunomodulatory effects. Compared with traditional 2D cultures of MSCs, 3D cultures of MSCs have emerged as an effective approach to enhance cell viability, proliferation, and functionality, and provide a more relevant physiological environment. Here, we review the therapeutic potential of 3D-cultured MSCs, highlighting their roles in tissue regeneration and repair and drug screening. We further summarize successful cases that apply 3D MSCs in modeling disease states, enabling the identification of novel therapeutic strategies. Despite these promising applications, we discuss challenges that remain in the clinical translation of 3D MSC technologies, including stability, cell heterogeneity, and regulatory issues. We conclude by addressing these obstacles and emphasizing the need for further research to fully exploit the potential of 3D MSCs in clinical practice.
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