淋巴瘤
医学
疾病
危险分层
循环肿瘤DNA
肿瘤科
霍奇金淋巴瘤
放射治疗
重症监护医学
内科学
癌症
作者
Jan‐Michel Heger,Justin Ferdinandus,Julia Mattlener,Sven Borchmann
标识
DOI:10.1053/j.seminhematol.2023.06.005
摘要
Hodgkin lymphoma is a B-cell lymphoma often affecting young adults. Outcomes following intensive chemo- and radiotherapy are generally favourable but leave patients at high risk for early and late toxicities frequently reducing quality of life. Relapsed/refractory disease is regularly difficult to treat and ultimately results in death in a relevant subset of patients. Current strategies for risk stratification and response evaluation rely on clinical features and imaging only, and lack discriminatory power to detect patients at risk for disease progression. Here, we explore how circulating tumor DNA sequencing might help to overcome these shortcomings. We provide an overview over recent technical and methodological developments and suggest potential use cases for different clinical situations. Circulating tumor DNA sequencing offers the potential to significantly augment current risk stratification strategies with the ultimate goal of further individualizing treatment strategies for patients with HL.
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