原细胞
编配
转导(生物物理学)
人工细胞
机制(生物学)
信号转导
生物
计算机科学
认知科学
神经科学
人工智能
细胞生物学
物理
生物物理学
心理学
艺术
视觉艺术
量子力学
遗传学
膜
音乐剧
作者
Xuanji Yu,Vincent Mukwaya,Stephen Mann,Hongjing Dou
标识
DOI:10.1002/smtd.202300231
摘要
In recent years, significant progress has been made in the emerging field of constructing biomimetic soft compartments with life-like behaviors. Given that biological activities occur under a flux of energy and matter exchange, the implementation of rudimentary signaling pathways in artificial cells (protocells) is a prerequisite for the development of adaptive sense-response phenotypes in cytomimetic models. Herein, recent approaches to the integration of signal transduction modules in model protocells prepared by bottom-up construction are discussed. The approaches are classified into two categories involving invasive biochemical signals or non-invasive physical stimuli. In the former mechanism, transducers with intrinsic recognition capability respond with high specificity, while in the latter, artificial cells respond through intra-protocellular energy transduction. Although major challenges remain in the pursuit of a sophisticated artificial signaling network for the orchestration of higher-order cytomimetic models, significant advances have been made in establishing rudimentary protocell communication networks, providing novel organizational models for the development of life-like microsystems and new avenues in protoliving technologies.
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