A natural extracellular matrix hydrogel through selective nutrient restriction for hyperinflammatory starvation therapy

(Matter 6, 397–428, February 1, 2023) In the originally published version of this article’s Supplemental Information, we used an incorrect image for P-ECM at 0 h in Figure S10B. Of note, only the image was incorrect; the values and description in the figure caption were accurate for all cases. Figure S10B has now been corrected online with the correct image. The authors apologize for any confusion this error may have caused.Figure S10BThe degradation of NPV-ECM (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) A natural extracellular matrix hydrogel through selective nutrient restriction for hyperinflammatory starvation therapyChen et al.MatterDecember 21, 2022In BriefIn an environment of excessive inflammation, adequate nutrient supply aggravates inflammation. We propose a “hyperinflammatory starvation therapy” by selectively restricting the supply of nutrients. Here we developed a nano-platelet vesicle-based extracellular matrix hydrogel (NPV-ECM). We demonstrated that the NPV-ECM can regulate nutrient transportation, remodel the immune microenvironment, limit excess metabolism, and achieve diabetic wound healing. This study provides a new way for the materials-based precise metabolic regulation. The NPV-ECM has broad application prospects for clinical excessive inflammatory diseases. Full-Text PDF