Dynamic oxygenation subgroup bringing new insights in ARDS: more predictive of outcomes and response to PEEP than static PaO2/FiO2

BACKGROUND: ) ratios from the day of ARDS diagnosis to day 3. The secondary objective was to determine whether these dynamic physiological subgroups are more effective in predicting patient outcomes and treatment response than the Berlin criteria-defined static oxygenation subgroups. METHODS: We used group-based trajectory modelling to construct longitudinal oxygenation subgroups over the first 3 days following ARDS diagnosis, based on five ARDS databases. Additionally, we compared these longitudinal subgroups with static Berlin criteria-defined mild, moderate and severe subgroups in terms of clinical characteristics, outcomes and positive end-expiratory pressure (PEEP) responses. RESULTS: development trajectory and PEEP treatment response, compared with the subgroup defined by the Berlin criteria. CONCLUSIONS: ratios in the ARDS Berlin criteria.