神经保护
神经退行性变
氧化应激
医学
神经科学
疾病
神经炎症
神经学
背景(考古学)
促炎细胞因子
炎症反应
炎症
生物信息学
药理学
免疫学
生物
病理
内科学
古生物学
作者
Kangzhe Xie,Hala El Khoury,John Mitrofanis,Paul J. Austin
出处
期刊:Reviews in The Neurosciences
[De Gruyter]
日期:2022-10-28
卷期号:34 (4): 459-481
被引量:5
标识
DOI:10.1515/revneuro-2022-0109
摘要
Abstract This systematic review examines the effect of photobiomodulation (PBM), the application of red to near infrared light on body tissues, on the neuroinflammatory response and oxidative stress in animal models of neurodegenerative diseases. The research question and search protocol were prospectively registered on the PROSPERO database. Neurodegenerative diseases are becoming ever more prevalent in the ageing populations across the Western world, with no disease-modifying or neuroprotective treatment options being available. Hence there is a real need for the development of effective treatment options for patients. Inflammatory responses and oxidative stress within the central nervous system have a strong correlation with neuronal cell death. PBM is a non-invasive therapeutic option that has shown efficacy and promising effects in animal models of neurodegenerative disease; many studies have reported neuroprotection and improved behavioural outcomes. To the best of our knowledge, there has been no previous study that has reviewed the anti-inflammatory and the antioxidant effect of PBM in the context of neurodegeneration. This review has examined this relationship in animal models of a range of neurodegenerative diseases. We found that PBM can effectively reduce glial activation, pro-inflammatory cytokine expression and oxidative stress, whilst increasing anti-inflammatory glial responses and cytokines, and antioxidant capacity. These positive outcomes accompanied the neuroprotection evident after PBM treatment. Our review provides further indication that PBM can be developed into an effective non-pharmacological intervention for neurodegenerative diseases.
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