碱性成纤维细胞生长因子
脊髓损伤
脂质体
血管生成
医学
成纤维细胞生长因子
病变
脊髓
癌症研究
生长因子
病理
内科学
材料科学
纳米技术
受体
精神科
作者
Fenzan Wu,Peng-Hui Wang,Xiaojie Wei,Yanhong Yang,Abdullah Al Mamun,Zhaoxiong Xie,Yunsen Zhu,Tingting Mo,Hongyu Zhang,Chang Jiang,Jie Hu,Jian Xiao
标识
DOI:10.1016/j.mtbio.2023.100546
摘要
Nanoparticle technologies offer a non-invasive means to deliver basic fibroblast growth factor (bFGF) for the treatment of spinal cord injury (SCI). However, the inability of bFGF to accumulate at the injury site and inefficient penetration across the blood-spinal cord barrier (BSCB) remain challenges. The present study describes a dual-targeting liposome (bFGF@Lip-Cp&Rp) with injury lesion targeting and BSCB-penetrating capability to deliver bFGF for SCI treatment. The CAQK peptide (Cp) with injury lesion targeting ability and R2KC peptide (Rp) with BSCB-penetrating capability were grafted onto the liposomes for a flexible and non-invasive drug delivery systems preparation. Results exhibit that the dual-targeted liposomes could significantly cross the BSCB and accumulate at the injury site. During the early stage of SCI, bFGF@Lip-Cp&Rp promotes repair of BSCB and facilitates M2-polarization of macrophages. Regular delivery of bFGF@Lip-Cp&Rp increase HUVECs tube formation and angiogenesis, ameliorate the microenvironment of lesion site, suppress the neuronal apoptosis and axonal atrophy in SCI rats. Importantly, continuous treatment of bFGF@Lip-Cp&Rp supports the restoration of limb motor function in SCI rats. In summary, this research implies that the injury site-targeting and BSCB-penetrating liposomes could be a promising therapeutic approach for the treatment of SCI.
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