旁侵犯
发病机制
病态的
医学
头颈部
前列腺癌
癌症
病理
癌症研究
内科学
外科
作者
Richard L. Bakst,Richard J. Wong
出处
期刊:Journal of neurological surgery
[Georg Thieme Verlag KG]
日期:2016-03-10
卷期号:77 (02): 096-106
被引量:83
标识
DOI:10.1055/s-0036-1571835
摘要
Perineural invasion (PNI) is the neoplastic invasion of nerves. PNI is widely recognized as an important adverse pathological feature of many malignancies, including pancreatic, prostate, and head and neck cancers and is associated with a poor prognosis. Despite widespread acknowledgment of the clinical significance of PNI, the mechanisms underlying its pathogenesis remain largely unknown. Recent theories of PNI pathogenesis have placed a significant emphasis on the active role of the nerve microenvironment, with PNI resulting from well-orchestrated reciprocal interactions between cancer and host. Elucidating the mechanisms involved in PNI may translate into targeted therapies for this ominous process.
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