511 Role of NLR (Nucleotide Oligomerization Domain (NOD)—like Receptor) on Allergic Inflammation in a Mouse Model of Allergic Rhinitis

Background Recently, a new set of pattern-recognition receptors, the nucleotidebinding oligomerization domain (Nod)-like receptors (NLRs), have emerged. Their activation, either by allergens or microbes, triggers an inflammatory response. Objective: To investigate whether recognition of bacterial microbial-associated molecular patterns in the nose may result in susceptibility to developing allergic reactions, and to understand the molecular mechanisms by which such triggers block natural tolerance.