Major Surgery Affects Memory in Individuals with Cerebral Amyloid-β Pathology

神经认知 医学 围手术期 认知 神经心理学 无症状的 生物标志物 骨科手术 内科学 外科 精神科 生物化学 化学
作者
Carmen Lage,Andrea González-Suárez,María Puerto Alcalde-Hierro,María Isabel Sampedro-González,María Ángeles Villanueva-Eguaras,Manuel Rubén Sánchez-Crespo,Catherine Widmann,Frederic Brosseron,Ana Pozueta,Sara López-García,María D. García-Martínez,Martha Kazimierczak,María Cristina Bravo-González,Andrea Fernández-Rodríguez,Marta Drake-Pérez,Juan Irure-Ventura,Marcos López-Hoyos,Eloy Rodríguez-Rodríguez,Michael T. Heneka,Pascual Sánchez-Juan
出处
期刊:Journal of Alzheimer's Disease [IOS Press]
卷期号:79 (2): 863-874 被引量:5
标识
DOI:10.3233/jad-191229
摘要

Background: Major surgery has been associated with perioperative neurocognitive disorders (PND), but the contributing factors and long-term prognosis are uncertain. We hypothesize that preclinical Alzheimer’s disease (AD) might predispose to cognitive deterioration after surgery. Objective: To analyze the effect of amyloid-β on the cognitive trajectory after orthopedic surgery in a sample of non-demented subjects. Methods: Non-demented individuals older than 65 years that were on the waiting list for orthopedic surgery with spinal anesthesia underwent a neuropsychological assessment before and after surgery. During surgery, cerebrospinal fluid samples were obtained to determine AD biomarkers. Results: Cumulative incidence of PND was 55.2%during a mean follow-up of nine months. The most affected cognitive domains were executive function and constructional praxis. The presence of abnormal levels of amyloid-β was associated to a postoperative impairment in verbal and visual memory tests. According to their AD biomarker profile, participants were categorized as either Amyloid Positive (A+) or Amyloid Negative (A-). The incidence of PND did not differ between both groups. The A- group showed a tendency similar to the global sample, worsening in executive function tests and improving on memory scales due to practice effects. In contrast, the A + group showed a notable worsening on memory performance. Conclusion: Our findings support the hypothesis that surgery may promote or accelerate memory decline in cognitively asymptomatic subjects with brain amyloid-β deposits.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
谷粱初之发布了新的文献求助10
1秒前
完美世界应助daihq3采纳,获得10
1秒前
开心肖肖乐完成签到 ,获得积分10
2秒前
3秒前
8秒前
9秒前
10秒前
10秒前
糕糕完成签到 ,获得积分10
11秒前
11秒前
复杂若男完成签到,获得积分20
12秒前
武雨寒发布了新的文献求助10
13秒前
Sir.夏季风发布了新的文献求助10
13秒前
刻苦羽毛发布了新的文献求助20
15秒前
daihq3发布了新的文献求助10
15秒前
吉以寒发布了新的文献求助10
16秒前
顾矜应助可靠的青采纳,获得10
20秒前
Heart完成签到,获得积分10
21秒前
彭于晏应助camille采纳,获得10
22秒前
香蕉觅云应助吉以寒采纳,获得10
22秒前
倩迷谜应助科研通管家采纳,获得10
23秒前
Hello应助科研通管家采纳,获得10
23秒前
23秒前
所所应助科研通管家采纳,获得10
23秒前
Lucas应助科研通管家采纳,获得10
23秒前
爆米花应助科研通管家采纳,获得10
23秒前
ldld完成签到,获得积分20
23秒前
董小天天完成签到,获得积分10
24秒前
cao发布了新的文献求助30
26秒前
26秒前
风花雪月完成签到 ,获得积分10
27秒前
27秒前
小二郎应助ldld采纳,获得10
29秒前
32秒前
Jasper应助Silver采纳,获得10
33秒前
Kashing发布了新的文献求助10
33秒前
zjwzcxy完成签到,获得积分20
33秒前
zjwzcxy发布了新的文献求助10
35秒前
37秒前
38秒前
高分求助中
Thermodynamic data for steelmaking 3000
Manual of Clinical Microbiology, 4 Volume Set (ASM Books) 13th Edition 1000
Cross-Cultural Psychology: Critical Thinking and Contemporary Applications (8th edition) 800
Counseling With Immigrants, Refugees, and Their Families From Social Justice Perspectives pages 800
マンネンタケ科植物由来メロテルペノイド類の網羅的全合成/Collective Synthesis of Meroterpenoids Derived from Ganoderma Family 500
Electrochemistry 500
Broflanilide prolongs the development of fall armyworm Spodoptera frugiperda by regulating biosynthesis of juvenile hormone 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2370968
求助须知:如何正确求助?哪些是违规求助? 2079425
关于积分的说明 5207038
捐赠科研通 1806762
什么是DOI,文献DOI怎么找? 901732
版权声明 558185
科研通“疑难数据库(出版商)”最低求助积分说明 481519