发病机制
小RNA
骨关节炎
生物
滑膜关节
软骨细胞
软骨
血管生成
生物信息学
表型
RNA干扰
细胞生物学
癌症研究
基因
医学
核糖核酸
遗传学
免疫学
病理
关节软骨
解剖
替代医学
作者
Chao He,Xin Jiang,Cheng Chen,Hai Bin Zhang,Wen Cao,Qi Wu,Chi Ma
出处
期刊:Bone and Joint Research
[British Editorial Society of Bone and Joint Surgery]
日期:2021-02-01
卷期号:10 (2): 122-133
被引量:24
标识
DOI:10.1302/2046-3758.102.bjr-2020-0228.r1
摘要
Osteoarthritis (OA), one of the most common motor system disorders, is a degenerative disease involving progressive joint destruction caused by a variety of factors. At present, OA has become the fourth most common cause of disability in the world. However, the pathogenesis of OA is complex and has not yet been clarified. Long non-coding RNA (lncRNA) refers to a group of RNAs more than 200 nucleotides in length with limited protein-coding potential, which have a wide range of biological functions including regulating transcriptional patterns and protein activity, as well as binding to form endogenous small interference RNAs (siRNAs) and natural microRNA (miRNA) molecular sponges. In recent years, a large number of lncRNAs have been found to be differentially expressed in a variety of pathological processes of OA, including extracellular matrix (ECM) degradation, synovial inflammation, chondrocyte apoptosis, and angiogenesis. Obviously, lncRNAs play important roles in regulating gene expression, maintaining the phenotype of cartilage and synovial cells, and the stability of the intra-articular environment. This article reviews the results of the latest research into the role of lncRNAs in a variety of pathological processes of OA, in order to provide a new direction for the study of OA pathogenesis and a new target for prevention and treatment. Cite this article: Bone Joint Res 2021;10(2):122–133.
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