鲍曼不动杆菌
细菌外膜
微生物学
生物膜
毒力
生物
大肠杆菌
病菌
细菌
抗生素
抗生素耐药性
铜绿假单胞菌
基因
生物化学
遗传学
作者
Dan Nie,Yinling Hu,Chen Zhou,Mingkai Li,Hui Zheng,Xiaoxing Luo,Xinggang Mao,Xiaoyan Xue
标识
DOI:10.1186/s12929-020-0617-7
摘要
Abstract Acinetobacter baumannii ( A. baumannii ) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulence factor which mediates bacterial biofilm formation, eukaryotic cell infection, antibiotic resistance and immunomodulation. The characteristics of OmpA in Escherichia coli ( E. coli ) have been extensively studied since 1974, but only in recent years researchers started to clarify the functions of OmpA in A. baumannii . In this review, we summarized the structure and functions of OmpA in A. baumannii (AbOmpA), collected novel therapeutic strategies against it for treating A. baumannii infection, and emphasized the feasibility of using AbOmpA as a potential therapeutic target.
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