清脆的
Cas9
基因组编辑
生物
回文
计算生物学
基因
DNA
功能(生物学)
反式激活crRNA
遗传学
作者
Su Li,Nan Wu,Donglin Sun
出处
期刊:Int J Genet
日期:2016-12-15
卷期号:39 (6): 316-320
标识
DOI:10.3760/cma.j.issn.1673-4386.2016.06.005
摘要
Clustered regularly interspaced short palindromic repeats (CRISPR), an adaptive immune defense mechanism in bacteria, together with its associated(Cas)protein forms CRISPR-Cas system, which defenses exogenous DNA invasion. TypeⅡCRISPR-Cas, also called CRISPR-Cas9, is used in developing new diagnostic and therapeutic approaches of single gene disorders, virosis and tumors because of its simple structure and function of editing target DNA. In this paper, we review the mechanisms and applications of CRISPR-Cas9.
Key words:
CRISPR-Cas9; Gene edition; Tumor
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