The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

The amyloid-␤ oligomer (A␤O) hypothesis was introduced in 1998.It proposed that the brain damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like A␤Os.This hypothesis was based on the discovery that fibril-free synthetic preparations of A␤Os were potent CNS neurotoxins that rapidly inhibited long-term potentiation and, with time, caused selective nerve cell death (Lambert et al., 1998).The mechanism was attributed to disrupted signaling involving the tyrosine-protein kinase Fyn, mediated by an unknown toxin receptor.Over 4,000 articles concerning A␤Os have been published since then, including more than 400 reviews.A␤Os have been shown to accumulate in an AD-dependent manner in human and animal model brain tissue and, experimentally, to impair learning and memory and instigate major facets of AD neuropathology, including tau pathology, synapse deterioration and loss, inflammation, and oxidative damage.As reviewed by Hayden and Teplow in 2013, the A␤O hypothesis "has all but supplanted the amyloid cascade."Despite the emerging understanding of the role played by A␤Os in AD pathogenesis, A␤Os have not yet received the clinical attention given to amyloid plaques, which have been at the core of major attempts at therapeutics and diagnostics but are no longer regarded as the most pathogenic form of A␤.However, if the momentum of A␤O research continues, particularly efforts to elucidate key aspects of structure, a clear path to a successful disease modifying therapy can be envisioned.Ensuring that lessons learned from recent, late-stage clinical failures are applied appropriately throughout therapeutic development will further enable the likelihood of a successful therapy in the near-term.